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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Review Article

Exploring 1,3,4-Oxadiazole Scaffold for Anti-inflammatory and Analgesic Activities: A Review of Literature From 2005-2016

Author(s): Gita Chawla*, Baby Naaz and Anees A. Siddiqui

Volume 18 , Issue 3 , 2018

Page: [216 - 233] Pages: 18

DOI: 10.2174/1389557517666170127121215

Price: $65


1,3,4-Oxadiazole derivatives are found to have a wide range of pharmacological activities and attracting the researchers to work on this nucleus. Literature survey indicates that many 1,3,4- oxadiazoles have been synthesized with the aim to get compounds of significant anti-inflammatory and analgesic activities with reduced adverse effects. The purpose of this review is to compile the reports on 1,3,4-oxadiazole derivatives possessing anti-inflammatory and analgesic activities. The review also includes the reports on 1,3,4-oxadiazole derivatives of existing NSAIDs in the last ten years.

Keywords: Analgesic, anti-inflammatory, scaffold, COX, 1, 3, 4-Oxadiazole, NSAIDs.

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