Abstract
Human African Trypanosomiasis (HAT), a neglected disease endemic in Sub- Saharan Africa, is usually fatal if left untreated. It is caused by the parasite Trypanosoma brucei, and is spread by the tsetse fly. The drugs currently available to treat HAT are few, and limited in efficacy. Furthermore, resistance towards these drugs is beginning to grow. In the last 25 years, only one advance has been made into HAT treatment and consequently, there is an increasing need for new drugs to be sought that are able to effectively treat this disease. This review provides a brief overview of drug discovery research for HAT, focusing on research published in the last four years, identifying new molecules with the potential to be developed into anti-HAT agents. The methods of drug discovery have been grouped into three key areas; new molecules inspired by known antitrypanosomal agents, target-based screening, and phenotypic screening.
Keywords: Human African Trypanosomiasis, Trypanosoma brucei, antitrypanosomal, drug discovery, phenotypic screening, target-based screening.
Current Medicinal Chemistry
Title:A Brief Review of Drug Discovery Research for Human African Trypanosomiasis
Volume: 24 Issue: 7
Author(s): Danica R. Cullen and Mauro Mocerino
Affiliation:
Keywords: Human African Trypanosomiasis, Trypanosoma brucei, antitrypanosomal, drug discovery, phenotypic screening, target-based screening.
Abstract: Human African Trypanosomiasis (HAT), a neglected disease endemic in Sub- Saharan Africa, is usually fatal if left untreated. It is caused by the parasite Trypanosoma brucei, and is spread by the tsetse fly. The drugs currently available to treat HAT are few, and limited in efficacy. Furthermore, resistance towards these drugs is beginning to grow. In the last 25 years, only one advance has been made into HAT treatment and consequently, there is an increasing need for new drugs to be sought that are able to effectively treat this disease. This review provides a brief overview of drug discovery research for HAT, focusing on research published in the last four years, identifying new molecules with the potential to be developed into anti-HAT agents. The methods of drug discovery have been grouped into three key areas; new molecules inspired by known antitrypanosomal agents, target-based screening, and phenotypic screening.
Export Options
About this article
Cite this article as:
Cullen R. Danica and Mocerino Mauro, A Brief Review of Drug Discovery Research for Human African Trypanosomiasis, Current Medicinal Chemistry 2017; 24 (7) . https://dx.doi.org/10.2174/0929867324666170120160034
DOI https://dx.doi.org/10.2174/0929867324666170120160034 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
Call for Papers in Thematic Issues
Advances in Medicinal Chemistry: From Cancer to Chronic Diseases.
The broad spectrum of the issue will provide a comprehensive overview of emerging trends, novel therapeutic interventions, and translational insights that impact modern medicine. The primary focus will be diseases of global concern, including cancer, chronic pain, metabolic disorders, and autoimmune conditions, providing a broad overview of the advancements in ...read more
Approaches to the treatment of chronic inflammation
Chronic inflammation is a hallmark of numerous diseases, significantly impacting global health. Although chronic inflammation is a hot topic, not much has been written about approaches to its treatment. This thematic issue aims to showcase the latest advancements in chronic inflammation treatment and foster discussion on future directions in this ...read more
Cellular and Molecular Mechanisms of Non-Infectious Inflammatory Diseases: Focus on Clinical Implications
The Special Issue covers the results of the studies on cellular and molecular mechanisms of non-infectious inflammatory diseases, in particular, autoimmune rheumatic diseases, atherosclerotic cardiovascular disease and other age-related disorders such as type II diabetes, cancer, neurodegenerative disorders, etc. Review and research articles as well as methodology papers that summarize ...read more
Chalcogen-modified nucleic acid analogues
Chalcogen-modified nucleosides, nucleotides and oligonucleotides have been of great interest to scientific research for many years. The replacement of oxygen in the nucleobase, sugar or phosphate backbone by chalcogen atoms (sulfur, selenium, tellurium) gives these biomolecules unique properties resulting from their altered physical and chemical properties. The continuing interest in ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
subject Index To Volume 1
Current Medicinal Chemistry - Anti-Infective Agents Emerging Concepts for the Treatment of Hematological Malignancies with Therapeutic Monoclonal Antibodies
Current Drug Targets Metabolomics in Drug Intolerance
Current Drug Metabolism Uteroplacental Circulation and Fetal Vascular Function and Development
Current Vascular Pharmacology The Role of FKBP5 in Mood Disorders: Action of FKBP5 on Steroid Hormone Receptors Leads to Questions About its Evolutionary Importance
CNS & Neurological Disorders - Drug Targets Immunomodulation and Anti-Cancer Activity of Polysaccharide-Protein Complexes
Current Medicinal Chemistry Ablation of TRPV1 Elevates Nocturnal Blood Pressure in Western Diet-fed Mice
Current Hypertension Reviews Pulmonary Tuberculosis in Various Gene Knockout Mice With Special Emphasis on Roles of Cytokines and Transcription Factors
Current Respiratory Medicine Reviews Inducible Nitric Oxide Synthase as a Possible Target in Hypertension
Current Drug Targets MicroRNAs: Tiny but Not Trivial
Current Genomics Current Concepts in the Management of Diabetic Polyneuropathy
Current Diabetes Reviews Intravenous Immunoglobulın Therapy in Dermatology: An Update
Inflammation & Allergy - Drug Targets (Discontinued) Hypersensitivity Reactions to Non-Steroidal Anti-Inflammatory Drugs
Current Drug Metabolism The Role of Berberine in the Multi-Target Treatment of Senile Dementia
Current Topics in Medicinal Chemistry Protein Transduction Domains and their Utility in Gene Therapy
Current Gene Therapy Treatment Modalities for Hepatocellular Carcinoma
Current Cancer Drug Targets The Many Roles of Statins in Ischemic Stroke
Current Neuropharmacology An Emerging Role of Endometrial Inflammasome in Reproduction: New Therapeutic Approaches
Protein & Peptide Letters Integrins: A Method of Early Intervention in the Treatment of Colorectal Liver Metastases
Current Pharmaceutical Design Fetal and Obstetric Manifestations in the Antiphospholipid Syndrome
Current Rheumatology Reviews