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Current Immunology Reviews (Discontinued)

Editor-in-Chief

ISSN (Print): 1573-3955
ISSN (Online): 1875-631X

Review Article

Role of IL-17F in the Pathogenesis of Psoriasis

Author(s): Masayuki Nakajima, Mio Kawaguchi, Hideaki Watanabe, Yuko Morishima, Shau-Ku Huang, Hiroaki Satoh and Nobuyuki Hizawa

Volume 12 , Issue 2 , 2016

Page: [112 - 117] Pages: 6

DOI: 10.2174/1573395513666161214121923

Price: $65

Abstract

Psoriasis is a complex autoimmune inflammatory disease with a genetic basis. The increased expression of IL-17F gene and protein is observed in the lesional skins of psoriatic patients. We and other groups discovered human IL-17F gene that shows the highest homology with IL-17A. IL-17F induces various inflammatory molecules, such as IL-6 and IL-8. IL-17F is mainly derived from Th17, Tc17 and ILC3 cells, and induces CCL20 expression, resulting in the recruitment of additional IL-17F-producing cells to enhance skin inflammation via CCR6. The receptor for IL-17F is the heterodimeric complex of IL-17RA and IL-17RC, and several signaling pathways have been identified. Injection with IL-17F in mice revealed marked neutrophilia in dermis, and its infiltration was significantly inhibited by anti-IL-8 antibody. Sequence variants of the IL-17F gene are associated with response to treatments, and a variant (rs763780) of IL-17F encodes an antagonist for the wild-type IL-17F. Hence, IL-17F may play a pivotal role in the pathogenesis of psoriasis, and may provide a promising therapeutic target for development of novel strategies.

Keywords: Psoriasis, IL-17 cytokine family, IL-17F.

Graphical Abstract

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