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Current Pediatric Reviews

Editor-in-Chief

ISSN (Print): 1573-3963
ISSN (Online): 1875-6336

Review Article

Five Pediatric Cancers – Update on Genetic Implications

Author(s): Stacy Cooper, Jeffrey Rubens and Joann Bodurtha*

Volume 13 , Issue 1 , 2017

Page: [42 - 48] Pages: 7

DOI: 10.2174/1573396312666161213114223

Price: $65

Abstract

Pediatric cancer has undergone significant improvements in survival over the past several decades, in part due to a better understanding of the underlying genetic aberrations of each oncologic diagnosis, which has allowed for more effective targeted therapies. Pediatric brain tumors, leukemia, lymphoma, Wilms tumor, and retinoblastoma are exemplary pediatric cancers that each has specific epidemiology regarding children at risk as well as characteristic associated genetic lesions. These genetic features are more commonly being used to provide risk stratification, as well as to identify novel pathways for targeted therapy. With these advances, the overall survival of pediatric cancers continues to be improved.

Keywords: Brain tumors, cancer, genetics, leukemia, lymphoma, pediatrics, retinoblastoma, wilms tumor.

Graphical Abstract

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