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Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Under Re-organization)


ISSN (Print): 1871-5222
ISSN (Online): 1875-6115

Research Article

Umbilical IgE and Advanced Glycation Products in Association with Allergies in Childhood

Author(s): Jiri Liska, Vaclav Holecek, Konrad Siala, Stepanka Sobotova, Ladislav Trefil, Jaroslav Racek, Josef Sykora and Franstisek Sefrna

Volume 16 , Issue 2 , 2016

Page: [142 - 146] Pages: 5

DOI: 10.2174/1871522216666161018145434

Price: $65


Background: Little is known regarding the possibility of predicting allergy in genetically susceptible individuals.

Objective: We endeavored to measure the levels of IgE, IgA and advanced glycation end products (AGEs) in the umbilical blood of newborns of allergic parents.

Method: We collected two groups of newborns, the first group of 20 subjects with nonatopic parents, and the second with 20 subjects with a history of allergy in one or both parents.

Results: Neonates born to parents with allergies had increased levels of AGEs in their umbilical cord blood.

Conclusion: This causes increased oxidative stress and an increased probability of allergy and asthma in a child ´s future. We therefore propose that such children should be followed with the aim of lowering AGEs and IgE throughout life.

Keywords: Advanced glycation end products, allergy, neonates, oxidative stress, immunoglobulin E, umbilical blood.

Graphical Abstract

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