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Current Topics in Medicinal Chemistry


ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Review Article

Hybrid Drugs as Potential Combatants Against Drug-Resistant Microbes: A Review

Author(s): Haythem A. Saadeh and Mohammad S. Mubarak

Volume 17 , Issue 8 , 2017

Page: [895 - 906] Pages: 12

DOI: 10.2174/1568026616666160927155251

Price: $65


Antimicrobial resistance to drugs is a serious threat to public health. Different strategies have been adopted to deal with antimicrobial resistance to known drugs, one such strategy is the use of drug hybrids; this is a promising strategy to address the growing problem of drug resistance. The present review covers the very recent examples of combining (hybrid) two standard drugs in a single molecule for combating antibiotic-resistant microorganisms, and to present evidence supporting that drug hybrids are the urgent and practical solution to stop or slow down the spread of drug resistance. In addition, this review provides a literature overview of antimicrobial hybrids of standard drugs and their impact on antimicrobial resistance, covering publications between 2015 and 2016.

Keywords: Drug resistant, Hybrids, Bacteria, Malaria, Staphylococcus, Tuberculosis

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