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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Review Article

Late-life Depression and Alzheimer Disease: A Potential Synergy of the Underlying Mechanisms

Author(s): Jerzy Leszek, Elżbieta Trypka, Euphrosyni Koutsouraki, Dimitrios Michmizos, Nagendra Sastry Yarla, Vadim V. Tarasov, Ghulam Md Ashraf and Gjumrakch Aliev*

Volume 25 , Issue 39 , 2018

Page: [5389 - 5394] Pages: 6

DOI: 10.2174/0929867323666160902152829

Price: $65


A number of biological and clinical characteristics typical of late life depression (LLD) have been suggested by recent research findings. The close association of LLD with cognitive impairment is now well documented and evidenced. However, it is still not clear whether it is depression that leads to cognitive decline, and in more severe cases, to dementia. The work presented in this review article suggests that depression and dementia frequently and strongly copresent, even if the causality remains largely opaque.

Keywords: Aging, Alzheimer disease, depression, dementia, BDNF late-life depression.

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