Abstract
A number of biological and clinical characteristics typical of late life depression (LLD) have been suggested by recent research findings. The close association of LLD with cognitive impairment is now well documented and evidenced. However, it is still not clear whether it is depression that leads to cognitive decline, and in more severe cases, to dementia. The work presented in this review article suggests that depression and dementia frequently and strongly copresent, even if the causality remains largely opaque.
Keywords: Aging, Alzheimer disease, depression, dementia, BDNF late-life depression.
Current Medicinal Chemistry
Title:Late-life Depression and Alzheimer Disease: A Potential Synergy of the Underlying Mechanisms
Volume: 25 Issue: 39
Author(s): Jerzy Leszek, Elżbieta Trypka, Euphrosyni Koutsouraki, Dimitrios Michmizos, Nagendra Sastry Yarla, Vadim V. Tarasov, Ghulam Md Ashraf and Gjumrakch Aliev*
Affiliation:
- Sechenov First Moscow State Medical University, 119991, Moscow,Russian Federation
Keywords: Aging, Alzheimer disease, depression, dementia, BDNF late-life depression.
Abstract: A number of biological and clinical characteristics typical of late life depression (LLD) have been suggested by recent research findings. The close association of LLD with cognitive impairment is now well documented and evidenced. However, it is still not clear whether it is depression that leads to cognitive decline, and in more severe cases, to dementia. The work presented in this review article suggests that depression and dementia frequently and strongly copresent, even if the causality remains largely opaque.
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Cite this article as:
Leszek Jerzy, Trypka Elżbieta, Koutsouraki Euphrosyni, Michmizos Dimitrios, Yarla Sastry Nagendra, Tarasov V. Vadim, Ashraf Md Ghulam and Aliev Gjumrakch*, Late-life Depression and Alzheimer Disease: A Potential Synergy of the Underlying Mechanisms, Current Medicinal Chemistry 2018; 25 (39) . https://dx.doi.org/10.2174/0929867323666160902152829
DOI https://dx.doi.org/10.2174/0929867323666160902152829 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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