The transition to menopause is associated with a myriad of physiological changes including unstable hormone levels (estrogen, progesterone) resulting in hot flashes, sleep deprivation, weight gain, mood swings and is associated with increased risk of osteoperosis and cardiometabolic disease. Exercise is a critical component of health and wellbeing at any age; however, it may be especially beneficial during and following menopause. Currently, there are no physical activity guidelines specific to post-menopausal women with obesity. However, strong evidence suggests that greater health benefits may be derived with higher levels of physical activity beyond current recommendations for adults. This review describes the potential benefits of exercise in this population, as well as reviewing current guidelines and considerations for exercise in this population.