Abstract
The ever increasing cases of microbial resistance pose a major threat to the scientific community and therefore the need for discovery and development of newer antimicrobial agents with novel mode of action is becoming critical. One of the ways to tackle this herculean problem is to generate hybrid molecules by combining two or more bioactive heterocyclic moieties in a single molecular platform. The review here describes published results of our research group’s endeavors towards development of potential new and safe antimicrobial agents with better effectiveness by using the hybrid approach. In the present review article the landscaping of heterocycles like 4-thiazolidinones, benzimidazole and quinoline are described. Compounds displaying two of more fold antimicrobial activity are included in the review.
Keywords: Antimicrobial agents, benzimidazole, bioactive heterocycles, hybrid molecules, 4-thiazolidinone, quinoline.
Mini-Reviews in Medicinal Chemistry
Title:Hybrid Bioactive Heterocycles as Potential Antimicrobial Agents: A Review
Volume: 16 Issue: 18
Author(s): Nisheeth Desai, Amit Trivedi, Unnat Pandit, Amit Dodiya, V. Kameswara Rao and Priyanka Desai
Affiliation:
Keywords: Antimicrobial agents, benzimidazole, bioactive heterocycles, hybrid molecules, 4-thiazolidinone, quinoline.
Abstract: The ever increasing cases of microbial resistance pose a major threat to the scientific community and therefore the need for discovery and development of newer antimicrobial agents with novel mode of action is becoming critical. One of the ways to tackle this herculean problem is to generate hybrid molecules by combining two or more bioactive heterocyclic moieties in a single molecular platform. The review here describes published results of our research group’s endeavors towards development of potential new and safe antimicrobial agents with better effectiveness by using the hybrid approach. In the present review article the landscaping of heterocycles like 4-thiazolidinones, benzimidazole and quinoline are described. Compounds displaying two of more fold antimicrobial activity are included in the review.
Export Options
About this article
Cite this article as:
Desai Nisheeth, Trivedi Amit, Pandit Unnat, Dodiya Amit, Rao Kameswara V. and Desai Priyanka, Hybrid Bioactive Heterocycles as Potential Antimicrobial Agents: A Review, Mini-Reviews in Medicinal Chemistry 2016; 16 (18) . https://dx.doi.org/10.2174/1389557516666160609075620
DOI https://dx.doi.org/10.2174/1389557516666160609075620 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Pulmonary Hypertension and Lung Transplantation
Current Hypertension Reviews Use of Diuretics in Women for Management of Hypertension
Current Hypertension Reviews Therapeutic Potential of Targeting Protease Activated Receptors in Cardiovascular Diseases
Current Pharmaceutical Design Immunophilins: Structures, Mechanisms and Ligands
Current Molecular Pharmacology Cardiac Amyloid - A Hidden Contributor to Cardiac Dysfunction Following Cardiac Surgery: Case Report and Literature Review
Current Cardiology Reviews Blocking Apoptotic Intracellular Signaling Cascades with Cell-Permeable Peptides
Current Signal Transduction Therapy Treatment of Takotsubo Cardiomyopathy
Current Pharmaceutical Design Therapeutic Targeting of Endothelial Dysfunction in Chronic Diabetic Complications
Recent Patents on Cardiovascular Drug Discovery Appreciating the Balance between Classical Interleukin (IL)-6 Receptor Signaling and IL-6 Trans-Signaling: Implications for Arthritis Progression
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Potassium Channels: Novel Emerging Biomarkers and Targets for Therapy in Cancer
Recent Patents on Anti-Cancer Drug Discovery Imaging Techniques as an Aid in the Early Detection of Cardiac Amyloidosis
Current Pharmaceutical Design Subject Index To Volume 2
Current Cardiology Reviews Geriatric Depression - Review for Primary Care
Current Psychiatry Reviews Malaria, Anti Malarial Drugs and the Role of Melatonin
Infectious Disorders - Drug Targets Matrix Metalloproteinases as Potential Targets in the Venous Dilation Associated with Varicose Veins
Current Drug Targets Toxicities of Immunosuppressive Treatment of Autoimmune Neurologic Diseases
Current Neuropharmacology Flavonoids as Anticancer Agents: Recent Progress and State of the Art?
Current Organic Chemistry Antiplatelet Therapy in TAVI: Current Clinical Practice and Recommendations
Current Pharmaceutical Design Predominant Expression of rTERTb, an Inactive TERT Variant, in the Adult Rat Brain
Protein & Peptide Letters Calcium Channel Blockers in the Management of Hypertension in the Elderly
Cardiovascular & Hematological Agents in Medicinal Chemistry