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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Review Article

Glycoconjugates of Quinolines: Application in Medicinal Chemistry

Author(s): Valentina Oliveri and Graziella Vecchio

Volume 16 , Issue 15 , 2016

Page: [1185 - 1194] Pages: 10

DOI: 10.2174/1389557516666160505115634

Price: $65


Compounds with the quinoline scaffold are widely investigated and offer a variety of therapeutical properties. A number of quinoline derivatives have been synthesized and among these there are glycoconjugated derivatives. Based on the interest for this family of compounds, we reviewed the different biological activities (molecular probes, antiinfective, antiproliferative, antiaggregant and antioxidant) and the potential applications in medicinal chemistry of quinoline glycoconjugates. This review wants to show an example of the glycoconjugation strategy which arose not only to modify the water solubility of the quinolines but also to influence their activity and targeting properties.

Keywords: Aggregation, bacteria, cancer, clioquinol, glycosides, infection, malaria, sugar.

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