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Current Immunology Reviews (Discontinued)

Editor-in-Chief

ISSN (Print): 1573-3955
ISSN (Online): 1875-631X

Review Article

Orchestrating HIV Neutralization by Secondary Immune Response- Mediated Induction of RF Antibodies

Author(s): Konstantin V. Suslov

Volume 12 , Issue 2 , 2016

Page: [118 - 124] Pages: 7

DOI: 10.2174/1573395512666160502115314

Price: $65

Abstract

Antibody-dependent enhancement of infection is among the main challenges for HIV vaccines. Neutralization-enhancing RF antibodies (NeRFa) arising against immune complexes during secondary immune response not only enhance the action of neutralizing antibodies but also make infectionenhancing antibodies neutralizing in a sensitized virus. NeRFa represent the oldest type of immune response since it protects a fetus with unformed immune system from maternally acquired infections. Vaccination with HIV gp120 glycoprotein each 3 weeks may be a strategy to induce NeRFa both in prophylactic and therapeutic immunizations. Twenty-fold reduction in amount of protein for secondary immunization is important for an optimal induction of NeRFa. Auto-vaccination via transient immune suppression with dexamethasone might be a promising way to induce NeRFa in HIV-infected patients.

Keywords: Rheumatoid factor, immune complexes, neutralization-enhancing RF antibodies, NeRFa, HIV, repeated immunization, HIV vaccine, dexamethasone.

Graphical Abstract

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