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Current Drug Safety


ISSN (Print): 1574-8863
ISSN (Online): 2212-3911

Case Studies

Nifedipine Induced Gingival Hyperplasia in Pregnancy: A Case Report

Author(s): Brochet M.S., Harry M. and Morin F.

Volume 12 , Issue 1 , 2017

Page: [3 - 6] Pages: 4

DOI: 10.2174/1574886311666160426141851

Price: $65


Background: It is known that calcium channel blockers are associated with a risk of gingival hyperplasia. These drugs are widely used in the management of gestational hypertensive disorders.

Case: A 27-year-old G1 woman presented with gingival hyperplasia at 27 weeks gestation during a hospitalisation for preeclampsia. She had been on nifedipine for hypertension for the last 9 weeks. Nifedipine was discontinued and replaced by methyldopa and already after 48 hours the gingival hyperplasia improved. She delivered two weeks later and the gingival hyperplasia resolved completely without surgical intervention. The Naranjo’s score was used to prove the nifedipine’s imputability.

Conclusion: This first case report of gingival hyperplasia induced by nifedipine in pregnancy could be used as a reference for clinicians in the management of this adverse effect during the pregnancy.

Keywords: Calcium channel blockers, dental management, gingival hyperplasia, nifedipine, preeclampsia, pregnancy.

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