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Current Pharmaceutical Biotechnology


ISSN (Print): 1389-2010
ISSN (Online): 1873-4316

Controlled Drug Delivery Using Microdevices

Author(s): Sharma T. Sanjay, Maowei Dou, Guanglei Fu, Feng Xu and XiuJun Li

Volume 17 , Issue 9 , 2016

Page: [772 - 787] Pages: 16

DOI: 10.2174/1389201017666160127110440

Price: $65


Therapeutic drugs administered systematically are evenly distributed to the whole body through blood circulation and have to cross many biological barriers before reaching the pathological site. Conventional drug delivery may make drugs inactive or reduce their potency as they may be hydrolyzed or degraded enzymatically and are rapidly excreted through the urinary system resulting in suboptimal concentration of drugs at the desired site. Controlled drug delivery aims to localize the pharmacological activity of the drug to the desired site at desired release rates. The advances made by micro/nanofluidic technologies have provided new opportunities for better-controlled drug delivery. Various components of a drug delivery system can be integrated within a single tiny micro/nanofluidic chip. This article reviews recent advances of controlled drug delivery made by microfluidic/nanofluidic technologies. We first discuss microreservoir-based drug delivery systems. Then we highlight different kinds of microneedles used for controlled drug delivery, followed with a brief discussion about the current limitations and the future prospects of controlled drug delivery systems.

Keywords: Controlled/targeted drug delivery, pharmacological activity, micro/nanofluidic technologies, microdevices, microreservoir, and microneedle.

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