Abstract
Metastasis, the main cause of mortality in cancer patients, is a complex process consisting of several sequential, interlinked, and highly-selective steps. Fibroblast growth factor-inducible 14 (Fn14) is one member of the tumor necrosis factor receptor family, which is influential in controlling cell division, life, and death. The role of Fn14 in tumor metastasis regulation is slowly being unraveled, including roles in the regulation of the epithelial-mesenchymal transition, angiogenesis, cytoskeleton modulation, extracellular matrix degradation and inflammation. This review will focus on recent studies that demonstrate the involvement of Fn14 in tumor progression and will briefly describe various pathways of Fn14-regulated metastasis. Finally, future prospects will be discussed for the potential role of Fn14 as a predictive marker and therapeutic agent for tumor metastasis suppression.
Keywords: Fn14, cancer, metastasis, targeted therapy, signal pathway.
Current Molecular Medicine
Title:Fibroblast Growth Factor-Inducible 14: Multiple Roles in Tumor Metastasis
Volume: 15 Issue: 10
Author(s): X. Wang, Y. Zeng, D. N. Ho, J. Yin, G. Liu and X. Chen
Affiliation:
Keywords: Fn14, cancer, metastasis, targeted therapy, signal pathway.
Abstract: Metastasis, the main cause of mortality in cancer patients, is a complex process consisting of several sequential, interlinked, and highly-selective steps. Fibroblast growth factor-inducible 14 (Fn14) is one member of the tumor necrosis factor receptor family, which is influential in controlling cell division, life, and death. The role of Fn14 in tumor metastasis regulation is slowly being unraveled, including roles in the regulation of the epithelial-mesenchymal transition, angiogenesis, cytoskeleton modulation, extracellular matrix degradation and inflammation. This review will focus on recent studies that demonstrate the involvement of Fn14 in tumor progression and will briefly describe various pathways of Fn14-regulated metastasis. Finally, future prospects will be discussed for the potential role of Fn14 as a predictive marker and therapeutic agent for tumor metastasis suppression.
Export Options
About this article
Cite this article as:
Wang X., Zeng Y., Ho D. N., Yin J., Liu G. and Chen X., Fibroblast Growth Factor-Inducible 14: Multiple Roles in Tumor Metastasis, Current Molecular Medicine 2015; 15 (10) . https://dx.doi.org/10.2174/1566524016666151123105752
DOI https://dx.doi.org/10.2174/1566524016666151123105752 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Lyn Regulates Cytotoxicity in Respiratory Epithelial Cells Challenged by Cigarette Smoke Extracts
Current Molecular Medicine Potential Therapeutic Application of the Association of Vitamins C and K3 in Cancer Treatment
Current Medicinal Chemistry DeepSSPred: A Deep Learning Based Sulfenylation Site Predictor Via a Novel nSegmented Optimize Federated Feature Encoder
Protein & Peptide Letters Chlorine, Chlorination By-Products and Their Allergic and Respiratory Health Effects
Current Respiratory Medicine Reviews Recent Insights into COVID-19 in Children and Clinical Recommendations
Current Pediatric Reviews Alzheimer’s Disease and Environmental Exposure to Lead: The Epidemiologic Evidence and Potential Role of Epigenetics
Current Alzheimer Research Mechanisms of Action of DNA-Damaging Anticancer Drugs in Treatment of Carcinomas: Is Acute Apoptosis an “Off-Target” Effect?
Mini-Reviews in Medicinal Chemistry Eplerenone, a New Selective Aldosterone Blocker
Current Pharmaceutical Design PET/CT With 68Ga-PSMA in Prostate Cancer: Radiopharmaceutical Background and Clinical Implications
Current Radiopharmaceuticals Circulatory Estrogen Level Protects Against Breast Cancer in Obese Women
Recent Patents on Anti-Cancer Drug Discovery Genetic Engineering - A New Era for Cancer Immunotherapy?
Current Cancer Therapy Reviews Cardiovascular Effects of EGFR (Epidermal Growth Factor Receptor) Monoclonal Antibodies
Cardiovascular & Hematological Agents in Medicinal Chemistry Bladder Cancer and Stem Cells
Current Signal Transduction Therapy Furan-induced Oxidative Stress and DNA Damage in Diabetic and Nondiabetic Rats’ Blood and Protective Effect of Lycopene
Current Nutrition & Food Science Gallium in Cancer Treatment
Current Topics in Medicinal Chemistry Surgical Treatment of Endometriosis
Current Women`s Health Reviews Targeting Sphingosine-1-Phosphate Receptors in Cancer
Anti-Cancer Agents in Medicinal Chemistry Physiology and Pharmacology of the Vanilloid Receptor
Current Neuropharmacology LRIGs: A Prognostically Significant Family with Emerging Therapeutic Competence against Cancers
Current Cancer Drug Targets The J-shaped Association Between Alcohol Consumption and Breast Cancer: A Case-Control Study
Current Nutrition & Food Science