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Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

A Review of Bisindolylmethane as an Important Scaffold for Drug Discovery

Author(s): Syahrul Imran, Muhammad Taha and Nor Hadiani Ismail

Volume 22 , Issue 38 , 2015

Page: [4412 - 4433] Pages: 22

DOI: 10.2174/0929867322666151006093930

Price: $65

Abstract

Bisindolylmethane and its derivatives are pharmacologically active and applicable in the field of pharmaceutical chemistry. Bisindolylmethanes have a variety of biological activities such as antihyperglycemic, antiinflammatory, antibacterial, anticancer, and antileishmanial activities, including enzyme inhibition activity. They play a crucial role in many diseases especially anticancer activity. Modifying their structure had proven to be useful in the search of new therapeutic agents. Extensive research carried out on bisindolylmethane and its derivatives shows that they are pharmacologically significant. The present review focuses on the pharmacological profile of bisindolylmethane derivatives. This review includes the current literature with an update of research findings as well as the perspectives that they hold for future research.

Keywords: Anticancer, anti-inflammation, bisindolylmethane, heterocycles, indole, pharmacological activities.


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