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Current Topics in Medicinal Chemistry


ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Magnetite Nanoshuttles for Fighting Staphylococcus aureus Infections: A Recent Review

Author(s): Alina Maria Holban

Volume 15 , Issue 16 , 2015

Page: [1589 - 1595] Pages: 7

DOI: 10.2174/1568026615666150414152431

Price: $65


In recent years, severe infections caused by the Gram positive pathogen Staphylococcus aureus have emerged both in community and clinical settings. The increased infection rates are explained by the versatility and resistance of this pathogen, which produces a wide arsenal of virulence factors, organize within difficult to eradicate biofilms and displays various resistance genes, leading current antibiotic therapies ineffective. Nanotechnological progress highlights the impact of magnetic nanoparticles in the current and future diagnosis and therapy procedures of the infectious diseases. These nanostructures could be used as efficient carriers for many natural and synthetic antimicrobials, which may be further utilized for the development of soluble anti-Staphylococcal formulations and improved surfaces and coatings of different uses, optimized to reduce attachment and biofilm formation.

Keywords: Biofilms, Magnetic nanoparticles, Novel antimicrobials, Resistant pathogens, Staphylococcus aureus, Virulence.

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