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Letters in Organic Chemistry


ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Synthesis, Spectral Characterization and Anticancer Activity of New 2,3,6- Substituted Quinazolin-4(3H)-one Derivatives

Author(s): Peddakonda Ramesh, Doddaga Srinivasulu, Polireddy Kishore, Valasani Koteswara Rao and Muttana Vijaya Bhaskara Reddy

Volume 12 , Issue 6 , 2015

Page: [385 - 393] Pages: 9

DOI: 10.2174/1570178612666150320233833

Price: $65


A series of ten new 2,3,6-substituted quinazolin-4(3H)-one derivatives (10a-j) were prepared from anthranilic acid (1) in a simple and economical path in a series of reactions and screened for their anticancer activity against pancreatic cancer cell line (PANC-1) using MTT assay. The results reveal that at concentration 100 µM/L, compounds 10b, 10f, 10g and 10h exhibited potential anticancer activity by inhibiting the growth of PANC-1 cells by >75% and remaining compounds showed moderate anticancer activity. The structural characterization of the synthesized compounds was elucidated by 1H & 13C NMR, LC-MS, FT-IR and elemental analysis. As potential anti-tumor agents, these new derivatives show promise for further research.

Keywords: Anthranilic acid, Pd catalyst, piperazine, quinazolin-4(3H)-ones, anticancer activity, pancreatic cancer cell line-1 (PANC-1).

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