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CNS & Neurological Disorders - Drug Targets


ISSN (Print): 1871-5273
ISSN (Online): 1996-3181

Cognitive Dysfunction in Depression: Lessons Learned from Animal Models

Author(s): Gislaine Z. Reus, Helena M. Abelaira, Daniela D. Leffa and Joao Quevedo

Volume 13 , Issue 10 , 2014

Page: [1860 - 1870] Pages: 11

DOI: 10.2174/1871527313666141130223453

Price: $65


Major depression is a serious public health problem and one of the most common psychiatric disorders, and it is estimated that millions of people are affected worldwide. In addition, patients having depression present cognitive impairments, which could influence treatment adherence and long-term outcomes. Although, studies have shown that alterations in the hypothalamic–pituitary–adrenal axis, in inflammatory and antioxidant systems, and changes in intracellular pathways are involved in the cognitive impairment verified in depressive patients, it was unclear how these alterations occur. In this context, animal models of psychiatric disorders are revealed as good alternatives for the study of pathophysiology of these and associated factors. Thus, this review will highlight studies with animal models that have helped in understanding the mechanisms involved in cognitive impairment associated with depression, as well as focus on effective treatments that assist in improving both depression and cognition.

Keywords: Animal models, cellular survival pathway, cognition, depression, immune system, neuroendocrine system.

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