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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Chemical Glycan Conjugation Controls the Biodistribution and Kinetics of Proteins in Live Animals

Author(s): A. Ogura, A. Kurbangalieva and K. Tanaka

Volume 14 , Issue 13 , 2014

Page: [1072 - 1077] Pages: 6

DOI: 10.2174/1389557514666141128101830

Price: $65


The biodistributions and in vivo kinetics of chemically prepared neoglycoproteins have been examined previously and are reviewed here. A variety of mono- and oligosaccharides may be conjugated onto a protein surface using chemical methods. The kinetics and organ-specific accumulation profiles of these glycoconjugates, introduced through intravenous injection, have been analyzed using conventional dissection studies as well as noninvasive methods, such as SPECT, PET, or fluorescence imaging. These studies have revealed glycan-dependent protein distribution kinetics that may be useful for pharmacological and diagnostic applications.

Keywords: Albumin, bioconjugation, biodistribution, chemical reaction, in vivo imaging, neoglycoprotein, N-glycans, tumor targeting.

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