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Current Pharmaceutical Biotechnology


ISSN (Print): 1389-2010
ISSN (Online): 1873-4316

Physiological Functions of Presenilins; Beyond γ-Secretase

Author(s): Ibolya Stiller, Beata Lizak and Gabor Banhegyi

Volume 15 , Issue 11 , 2014

Page: [1019 - 1025] Pages: 7

DOI: 10.2174/1389201015666141122204139

Price: $65


Presenilin (PS) was identified in screens for mutations causing the early onset forms of familial Alzheimer's disease (FAD) in 1995. As catalytic units of the γ-secretase complex, presenilins participate in the processing of amyloid beta protein (Aβ), the main component of deposits in brain of patients with AD. The more than 90 substrates of γ-secretase isolated so far demonstrate its contribution to wide range of cellular processes and signaling events. However, recent findings have revealed numerous γ-secretase-independent presenilin functions, including involvement in calcium homeostasis, endoplasmic reticulum (ER) stress and autophagy. This mini-review attempts to summarize the multiple physiological and pathological functions of presenilin.

Keywords: Autophagy, Ca2+ signaling, presenilin, ER stress, γ-secretase, neurodegenerative disease.

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