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Central Nervous System Agents in Medicinal Chemistry


ISSN (Print): 1871-5249
ISSN (Online): 1875-6166

Novel Histone Deacetylase Inhibitors for the Treatment of Pediatric Brain Tumors

Author(s): Pamela V. de Andrade, Augusto F. Andrade, Rosane G. de Paula Queiroz, Felipe A. Trevisan, Luiz G. Tone and Elvis T. Valera

Volume 14 , Issue 2 , 2014

Page: [90 - 95] Pages: 6

DOI: 10.2174/1871524914666141112093541

Price: $65


Pediatric brain tumors (BT) represent a broad group of malignancies that affect children, displaying different degrees of aggressiveness and prognosis. Current studies demonstrate a crosslink between genetic and epigenetic changes within these tumors. Histone modifications are key elements in the pathogenesis of cancer in general and in brain tumors in particular. It is well documented that at least two classes of enzymes control acetylation of histones: histone acetyltransferases (HATs) and histone deacetylase (HDACs). Transformed HAT or HDAC action was identified in a number of human tumors. It has been hypothesized that HDACs regulate gene expression by deacetylating important genes for cell maintenance. Several HDACs inhibitors have been characterized in the last years and have been shown to promote growth blockage, differentiation and apoptosis in various types of tumors, including glioblastomas, medulloblastomas, neuroblastomas, melanomas, and leukemias. Some of these inhibitors are currently under clinical investigation for different cancer treatments. This review summarizes important mechanisms of histone modifications and discusses recent discoveries with impact on the pre-clinical and clinical field of pediatric brain tumor treatment.

Keywords: Epigenetics, gene expression, histone deacetylase inhibitors, histone deacetylase, histone modification, pediatric brain tumors.

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