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Current Pharmaceutical Design

Editor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Dendritic Cells: A Double-Edge Sword in Atherosclerotic Inflammation

Author(s): Dimitry A. Chistiakov, Igor A. Sobenin, Alexander N. Orekhov and Yuri V. Bobryshev

Volume 21 , Issue 9 , 2015

Page: [1118 - 1123] Pages: 6

DOI: 10.2174/1381612820666141013162528

Price: $65

Abstract

Functional heterogeneity of dendritic cells (DCs) observed in atherosclerosis suggest for their complex and multifaced role in the pathogenesis of atherosclerotic disease. A delicate balance between anti-inflammatory and pro-inflammatory mechanisms drives atherogenesis, and local microenvironment triggers the actual involvement of DCs in atherosclerosis-associated inflammation. Responding to microenvironment stimuli, DCs contribute to atherogenesis in both ways being involved in supporting proatherogenic vascular inflammation and by suppressing inflammatory responses via induction of self-tolerogenic properties and regulatory T cells (Tregs). The local microenvironment and extrinsic stimuli influence DC phenotype and hence could control the phenotypic switch toward inflammation or tolerance.

Keywords: Atherosclerosis, arteriosclerosis, arteries, inflammation, dendritic cells, plasmacytoid dendritic cells.


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