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Current Signal Transduction Therapy

Editor-in-Chief

ISSN (Print): 1574-3624
ISSN (Online): 2212-389X

A Hypothesis for Regenerative Therapy for Neuronal Disease: Stem Cells within Artificial Niche

Author(s): Jialin Liu, Zhiwen Zhang, Jinghui Xue, Haitao Zhang, Yuxiao Liu and Fengyun Hu

Volume 9 , Issue 1 , 2014

Page: [38 - 43] Pages: 6

DOI: 10.2174/1574362409666140820225940

Price: $65

Abstract

Stem cells, which maintain self-renewal behavior and produce multiple mature cells, are recognized to be the best cell source for transplantation in regenerative medicine. Recently, stem-cell based transplantation has become an important pre-clinical attempt for neuronal injury and degeneration diseases, such as spinal cord injury, amyotrophic lateral sclerosis, and Alzheimer disease. However, the poor survival rate of stem cells and only a limited number of induced neurons from the cells were found in pre-clinical trials. Therefore, it is necessary to develop a rational procedure for stem cells transplantation. This review summarizes recent promising progress in the investigation of stem cell and biomaterials, and hypothesizes a useful transplant approach for stem cell therapy in neuronal diseases.

Keywords: Neuronal regenerative, stem cell therapy, transplantation therapy.


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