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Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Synthesis of Some New Chromeno[2,3-b]pyridine and [1,2,4]Triazolo[1,5- a]quinoline Nucleoside Analogues with Expected Biological Activity

Author(s): Amira A. Ghoneim and Ahmed F. El-Farargy

Volume 12 , Issue 1 , 2015

Page: [13 - 20] Pages: 8

DOI: 10.2174/1570178611666140304000403

Price: $65

Abstract

Direct preparation of 2-amino-5,6,7,8-tetrahydro-4-(4-methoxyphenyl)-7,7-dimethyl-5-oxo-4H-chromene-3- carbonitrile (2) and 1,2-diamino-1,4,5,6,7,8-hexahydro-4-(4-methoxyphenyl)-7,7-dimethyl-5-oxo-3-quinolinecarbonitrile (11) which were utilized as starting products for the synthesis of S-nucleoside analogues of kinds 10, 15 and C-nucleoside analogues of types 12, 13 is presented in the current study. The antibacterial and antifungal activities of these new compounds were evaluated. The structures of the new products were confirmed on the basis of elemental and spectral analysis results.

Keywords: Chromeno[2, 3-b]pyridines, [1, 2, 4]triazolo[1, 5-a]quinolines, L-rhamnopyranosyl bromide, antimicrobial activity.

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