Abstract
This review provides a brief summary of thiadiazole ring containing compounds as antidiabetic agents. It covers the most active thiadiazole derivatives selected from reported literature of thiadiazole system as antidiabetic drug substance in the form of synthesis and structural activity relationship study reports. Some of the promising thiadiazole compounds interacting with targets such as sodium-glucose linked transporter, peroxisome proliferator-activated receptor, protein tyrosine phosphatase, c-Jun N-terminal kinase, dipeptidyl peptidase-4 and cannabinoid-1 receptor have been collected with their biological potency. The information provided in this review acts as important overview for medicinal chemist to develop a new chemical entity possessing antidiabetic activity.
Keywords: Antidiabetic, cannabinoid-1 receptor, c-Jun N-terminal kinase, dipeptidyl peptidase-4, peroxisome proliferatoractivated receptor, protein tyrosine phosphatase, sodium-glucose linked transporter, thiadiazole.
Mini-Reviews in Medicinal Chemistry
Title:Development of Thiadiazole as an Antidiabetic Agent- A Review
Volume: 14 Issue: 2
Author(s): Prasanna A. Datar and Tejashree A. Deokule
Affiliation:
Keywords: Antidiabetic, cannabinoid-1 receptor, c-Jun N-terminal kinase, dipeptidyl peptidase-4, peroxisome proliferatoractivated receptor, protein tyrosine phosphatase, sodium-glucose linked transporter, thiadiazole.
Abstract: This review provides a brief summary of thiadiazole ring containing compounds as antidiabetic agents. It covers the most active thiadiazole derivatives selected from reported literature of thiadiazole system as antidiabetic drug substance in the form of synthesis and structural activity relationship study reports. Some of the promising thiadiazole compounds interacting with targets such as sodium-glucose linked transporter, peroxisome proliferator-activated receptor, protein tyrosine phosphatase, c-Jun N-terminal kinase, dipeptidyl peptidase-4 and cannabinoid-1 receptor have been collected with their biological potency. The information provided in this review acts as important overview for medicinal chemist to develop a new chemical entity possessing antidiabetic activity.
Export Options
About this article
Cite this article as:
Datar A. Prasanna and Deokule A. Tejashree, Development of Thiadiazole as an Antidiabetic Agent- A Review, Mini-Reviews in Medicinal Chemistry 2014; 14 (2) . https://dx.doi.org/10.2174/1389557513666140103102447
DOI https://dx.doi.org/10.2174/1389557513666140103102447 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
Call for Papers in Thematic Issues
Bioprospecting of Natural Products as Sources of New Multitarget Therapies
According to the Convention on Biological Diversity, bioprospecting is the exploration of biodiversity and indigenous knowledge to develop commercially valuable products for pharmaceutical and other applications. Bioprospecting involves searching for useful organic compounds in plants, fungi, marine organisms, and microorganisms. Natural products traditionally constituted the primary source of more than ...read more
Computational Frontiers in Medicinal Chemistry
The thematic issue "Computational Frontiers in Medicinal Chemistry" provides a robust platform for delving into state-of-the-art computational methodologies and technologies that significantly propel advancements in medicinal chemistry. This edition seeks to amalgamate top-tier reviews spotlighting the latest trends and breakthroughs in the fusion of computational approaches, including artificial intelligence (AI) ...read more
Natural Products and Dietary Supplements in Alleviation of Metabolic, Cardiovascular, and Neurological Disorders
Metabolic disorders like diabetes, obesity, inflammation, oxidative stress, cancer etc, cardiovascular disorders like angina, myocardial infarction, congestive heart failure etc as well as neurological disorders like Alzheimer?s, Parkinson?s, Epilepsy, Depression, etc are the global burden. They covered the major segment of the diseases and disorders from which the human community ...read more
Natural Products in Drug Discovery
Natural products have always been one of the important ways of drug discovery due to their novel skeleton and diverse functional group characteristics. According to statistics, between 1981 and 2019, the FDA approved a total of 1,394 small molecule drugs for marketing, of which 930 marketed drugs originated from the ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Thyroid Diseases During Pregnancy: Bibliometric Analysis of Scientific
Publications
Endocrine, Metabolic & Immune Disorders - Drug Targets Insulin Therapy, Insulin Resistance and Vascular Dysfunction
Current Vascular Pharmacology Dendritic Cells: A New Player in Osteoimmunology
Current Molecular Medicine A Proposal for a New Classification of Type 1 Diabetes Mellitus Based on Clinical and Immunological Evidence
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery Targeting the Multifaceted HuR Protein, Benefits and Caveats
Current Drug Targets Polycystic Ovary Syndrome and Infertility: From Molecular Perspective
Current Women`s Health Reviews Impact and Therapeutic Potential of PPARs in Alzheimers Disease
Current Neuropharmacology Antioxidants in Treating Pathologies Involving Oxidative Damage: An Update on Medicinal Chemistry and Biological Activity of Stobadine and Related Pyridoindoles
Current Medicinal Chemistry The Future of Diabetes Management by Healthy Probiotic Microorganisms
Current Diabetes Reviews Premature Adrenarche and its Association with Cardiovascular Risk in Females
Current Pharmaceutical Design Inhibition of Topoisomerase I by Anti-Cancer Drug Altered the Endometrial Cyclicity and Receptivity
Current Molecular Medicine Blockade of Renin Angiotensin System in Heart Failure Post-Myocardial Infarction: What is the Best Therapy?
Recent Patents on Cardiovascular Drug Discovery Beneficial Extracardiac Effects of Cardiovascular Medications
Current Cardiology Reviews The Vitamin D Saga: Breaking Dawn
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) HLA-G - From Fetal Tolerance to a Regulatory Molecule in Inflammatory Diseases
Current Immunology Reviews (Discontinued) The Optimal Treatment of Severe Hypertension in Pregnancy: Update of the Role of Nicardipine
Current Pharmaceutical Biotechnology Global Account of Barriers and Facilitators of Physical Activity Among Patients with Diabetes Mellitus: A Narrative Review of the Literature
Current Diabetes Reviews Near Infrared Spectroscopy in Healthy Preterm and Term Newborns: Correlation with Gestational Age and Standard Monitoring Parameters
Current Neurovascular Research Placental Transport of Folate and Thiamine: A Mini-Review
Current Women`s Health Reviews Vaginal Birth After Cesarean: How to Counsel Patients Using the Evidence
Current Women`s Health Reviews