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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Metal-N-Heterocyclic Carbene Complexes as Anti-Tumor Agents

Author(s): Chunqi Hu, Xin Li, Wei Wang, Ruoyu Zhang and Liping Deng

Volume 21 , Issue 10 , 2014

Page: [1220 - 1230] Pages: 11

DOI: 10.2174/0929867321666131217161849

Price: $65


It has been a long story of the development of anticancer metallopharmaceuticals since the identification of cisplatin. Advances in metallodrugs discovery during the past 40 years have made it an ever-growing area of research in medicinal inorganic chemistry. Meanwhile, the emerging of N-heterocyclic carbene (NHC) chemistry has stimulated the newly burgeoning interests in the biomedical applications of metal-NHC complexes. This review will detail what have been achieved hitherto in the research of metal-NHC complexes as potential anti-tumor agents coupled with gold, silver, copper, platinum and palladium. Their mechanism of action will also be discussed. All the results obtained indicate that this promising approach is worthy of more focuses and further studies.

Keywords: NHCs, NHC-metal complexes, anti-tumor, biological evaluation.

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