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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Naturally Occurring Methyl Salicylate Glycosides

Author(s): Ping Mao, Zizhen Liu, Meng Xie, Rui Jiang, Weirui Liu, Xiaohong Wang, Shen Meng and Gaimei She

Volume 14 , Issue 1 , 2014

Page: [56 - 63] Pages: 8

DOI: 10.2174/1389557513666131211110004

Price: $65


As an important part of non steroids anti-inflammation drug (NSAIDs), salicylate has developed from natural substance salicylic acid to natrium salicylicum, to aspirin. Now, methyl salicylate glycoside, a new derivative of salicylic acid, is modified with a -COOH group integrated one methyl radical into formic ether, and a -OH linked with a monosaccharide, a disaccharide or a trisaccharide unit by glycosidic linkage. It has the similar pharmacological activities, anti-inflammatory, analgesic, antipyretic and antithrombotic as the previous salicylates’ without resulting in serious side effects, particularly the gastrointestinal toxicity. Owing to the superiority of those significant bioactivities, methyl salicylate glycosides have became a hot research area in NSAIDs for several years. This paper compiles all 9 naturally occurring methyl salicylate glycosides, their distribution of the resource and pharmacological mechanism, which could contribute to the new drug discovery.

Keywords: Analgesic, anti-inflammation, antipyretic, methyl salicylate glycoside, NSAIDs.

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