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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Inhibition of P450 17 as a New Strategy for the Treatment of Prostate Cancer

Author(s): F. Leroux

Volume 12 , Issue 14 , 2005

Page: [1623 - 1629] Pages: 7

DOI: 10.2174/0929867054367185

Price: $65


The cytochrome P450 monooxygenase enzyme system is involved in the synthesis and/or degradation of a large number of endogenous compounds and in the biotransformation of drugs and other xenobiotics. 17α-Hydroxylase-C17,20-lyase (P450 17, CYP 17) is the key enzyme of the androgen biosynthesis. As androgens have been implicated in the development and progression of prostate cancer, this enzyme has become a promising therapeutic target. This paper will review the possible approaches dealing with P450 17 inhibition as a chemotherapeutic strategy in the struggle against prostate cancer.

Keywords: androgen, hydroxylase-c, lyase, cyp, prostate cancer, steroidal inhibitors, non-steroidal inhibitors, abiraterone, liarozole

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