Abstract
The aim of present study was to evaluate the impact of various combinations of nonionic surfactants on selfnanoemulsification efficiency of Sefsol-218 in glibenclamide nanoemulsion. Surfactants Labrasol, HCO-60, Tween-80, Cremophor-EL and Gelucire-44/14 along with cosurfactants Transcutol-HP, isopropyl alcohol and ethanol were investigated for this purpose. Formulations were prepared by spontaneous emulsification method and subjected for thermodynamic stability and self-nanoemulsification test. Only those formulations which were found to be stable at various stress conditions of thermodynamic stability and selfnanoemulsification tests were further characterized in terms of droplet size, viscosity, refractive index and % transmittance. Formulations prepared with Labrasol or Gelucire-44/14 were found to be suitable for self-emulsifying drug delivery system only whereas those prepared using HCO-60, Tween-80 and Cremophor-EL were found to be suitable for self-nanoemulsifying drug delivery system or selfmicroemulsifying drug delivery system. Based on lowest droplet size (39.1 nm), optimal values of polydispersity index (0.292) & refractive index (1.332), lowest viscosity (34.3 cp) and highest % transmittance (99.6), formulation S23 (Sefsol-218/Cremophor- EL/ethanol/water) was optimized as best formulation for self-nanoemulsifying drug delivery system of glibenclamide. These results indicated that Cremophor-EL could be the best surfactant in terms of self-nanoemulsification.
Keywords: Self-nanoemulsification efficiency, glibenclamide, surfactants, Sefsol-218, droplet size.
Current Nanoscience
Title:Impact of Mixed Nonionic Surfactants on Self-Nanoemulsification Efficiency of Sefsol-218 in Glibenclamide Nanoemulsion
Volume: 9 Issue: 6
Author(s): Faiyaz Shakeel, Nazrul Haq, Fars K. Alanazi and Ibrahim A. Alsarra
Affiliation:
Keywords: Self-nanoemulsification efficiency, glibenclamide, surfactants, Sefsol-218, droplet size.
Abstract: The aim of present study was to evaluate the impact of various combinations of nonionic surfactants on selfnanoemulsification efficiency of Sefsol-218 in glibenclamide nanoemulsion. Surfactants Labrasol, HCO-60, Tween-80, Cremophor-EL and Gelucire-44/14 along with cosurfactants Transcutol-HP, isopropyl alcohol and ethanol were investigated for this purpose. Formulations were prepared by spontaneous emulsification method and subjected for thermodynamic stability and self-nanoemulsification test. Only those formulations which were found to be stable at various stress conditions of thermodynamic stability and selfnanoemulsification tests were further characterized in terms of droplet size, viscosity, refractive index and % transmittance. Formulations prepared with Labrasol or Gelucire-44/14 were found to be suitable for self-emulsifying drug delivery system only whereas those prepared using HCO-60, Tween-80 and Cremophor-EL were found to be suitable for self-nanoemulsifying drug delivery system or selfmicroemulsifying drug delivery system. Based on lowest droplet size (39.1 nm), optimal values of polydispersity index (0.292) & refractive index (1.332), lowest viscosity (34.3 cp) and highest % transmittance (99.6), formulation S23 (Sefsol-218/Cremophor- EL/ethanol/water) was optimized as best formulation for self-nanoemulsifying drug delivery system of glibenclamide. These results indicated that Cremophor-EL could be the best surfactant in terms of self-nanoemulsification.
Export Options
About this article
Cite this article as:
Shakeel Faiyaz, Haq Nazrul, Alanazi K. Fars and Alsarra A. Ibrahim, Impact of Mixed Nonionic Surfactants on Self-Nanoemulsification Efficiency of Sefsol-218 in Glibenclamide Nanoemulsion, Current Nanoscience 2013; 9 (6) . https://dx.doi.org/10.2174/157341371130900100
DOI https://dx.doi.org/10.2174/157341371130900100 |
Print ISSN 1573-4137 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6786 |
Call for Papers in Thematic Issues
Role of nanomaterials in fabrication of coatings, Machining and Joining
The application of nanoscience has brought about a revolution in the field of mechanical engineering by providing novel materials, boosting manufacturing processes, and generating cutting-edge products. The purpose of this special issue is to investigate the enormous impact that nanoscience has had on mechanical engineering, with a particular emphasis on ...read more
Advanced Inorganic Nanocomposites and Their Emerging Applications
This special issue collection will highlight developments on the recent trends about the synthesis of metal oxides, nanoclusters, biomaterials, 2D nanomaterials, nanocrystals, nanocomposites, etc. and their applications in electrochemical systems, tissue regeneration, energy storage and harvesting, sensors, etc. The novelty of the methods in the chemical synthesis and their characterizations, ...read more
Applicability of Nanotechnology for Performance Enhancement of Clean Energy Technologies
Population growth, industrialization, and improvement in living quality would lead to further increase in energy demand in near future. Regarding the disadvantages of fossil fuels such as fluctuations in their price, high emissions of greenhouse gases and restriction of their sources, it is crucial to use and exploit alternative energy ...read more
Graphene and 2D Materials for Energy Storage and Conversion
This thematic issue will discuss the recent advances in graphene-based nanomaterials for different energy technologies. Graphene possesses a high surface area, and stable structure and exhibits many interesting electronic, optical, and mechanical properties due to its 2D crystal structure. Graphene is of both fundamental interest and suitable for a wide ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Annual Trends in Use of Periconceptional Folic Acid and Birth Prevalence of Major Congenital Malformations
Current Drug Safety Editorial (Hot Topic: Hypertension: A Serious Complication in Pregnancy)
Current Hypertension Reviews Gender Disparity in Pediatric Diseases
Current Molecular Medicine Getting to Know the Cast - Cellular Interactions and Signaling at the Neurovascular Unit
Current Pharmaceutical Design Vasotrophic Regulation of Age-Dependent Hypoxic Cerebrovascular Remodeling
Current Vascular Pharmacology Acrylamide Induced Toxicity and the Propensity of Phytochemicals in Amelioration: A Review
Central Nervous System Agents in Medicinal Chemistry Complex Obesity
Current Pediatric Reviews The Impact of Pregnancy and Parity on Type 1 Diabetes Complications
Current Diabetes Reviews Effect of Fetal and Neonatal Hypothyroidism on Glucose Tolerance in Middle- Aged Female Rats
Endocrine, Metabolic & Immune Disorders - Drug Targets Age-Related Changes and Effects of Mild Hypothermia on Carotid Artery Reactivity in Newborn Rats
CNS & Neurological Disorders - Drug Targets Vitamin D and Asthma: Scientific Promise and Clinical Reality
Current Respiratory Medicine Reviews Role of Iodine, Selenium and Other Micronutrients in Thyroid Function and Disorders
Endocrine, Metabolic & Immune Disorders - Drug Targets Therapeutic Window, a Critical Developmental Stage for Stem Cell Therapies
Current Stem Cell Research & Therapy Involvement of Intracellular pH in Vascular Insulin Resistance
Current Vascular Pharmacology Erythropoietin and Oxidative Stress
Current Neurovascular Research Arrhythmias and Left Ventricular Hypertrabeculation/Noncompaction
Current Pharmaceutical Design The Adipose Tissue in Farm Animals: A Proteomic Approach
Current Protein & Peptide Science Use of New Therapeutic Compounds in Pregnancy with Renal Disease
Current Women`s Health Reviews The GLUTs Family - Lessons from Transgenic Mice
Current Medicinal Chemistry - Immunology, Endocrine & Metabolic Agents Breastfeeding Policy Development and the Prevention of Obesity
Current Pediatric Reviews