Generic placeholder image

Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Recent Development in [1,4]Benzodiazepines as Potent Anticancer Agents: A Review

Author(s): Rupinder Kaur Gill, Shiv Om Kaushik, Jasreen Chugh, Sumit Bansal, Anamik Shah and Jitender Bariwal

Volume 14 , Issue 3 , 2014

Page: [229 - 256] Pages: 28

DOI: 10.2174/13895575113139990081

Price: $65

Abstract

The [1,4]benzodiazepine is an important class of heterocyclic compounds and clinically used for many ailments in humans. The [1,4]benzodiazepine has unique structure that mimics the peptide linkage. This interesting observation completely shifted the interest of medicinal chemist for [1,4]benzodiazepine from CNS acting drugs to anticancer agents. During last few decades, a large number of reports have appeared in the literature highlighting the anticancer activity of [1,4]benzodiazepines. Here, in this article, we have discussed the brief synthesis, origin of [1,4]benzodiazepines as anticancer agent, their mechanism of action and latest developments in this field. We have compiled the most important literature reports from last few decades till date.

Keywords: Anticancer, [1, 4]Benzodiazepines, DNA intercalating agents, Pyrrolo[1, 4]benzodiazepine, Antiarrhythmic agents, 2-Azidobenzoylchloride, Histone deacetylase inhibitors, Columbic interactions.


Rights & Permissions Print Export Cite as
© 2022 Bentham Science Publishers | Privacy Policy