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Current Pharmaceutical Design

Editor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Generation of Human Cardiomyocytes for Cardiac Regenerative Therapies: Differentiation and Direct Reprogramming

Author(s): Chani Hodonsky, Kaihong Wu, Lakshmi Mundada and Ming-Sing Si

Volume 20 , Issue 12 , 2014

Page: [2012 - 2022] Pages: 11

DOI: 10.2174/13816128113199990448

Price: $65

Abstract

The generation of functional human cardiomyocytes carries the potential of replacing damaged, malformed, or congenitally absent cardiac tissue as a definitive cure for cardiac disease. Furthermore, patient-specific cardiomyocytes may yield useful in vitro models of heart tissue for disease investigation, drug development and personalized therapy evaluation. This field has experienced rapid advances in the past few years. Nearly pure populations of cardiomyocytes have been generated from human pluripotent stem cells and new strategies to generate cardiomyocytes from somatic cells have been introduced. Here we review the latest breakthroughs in cardiomyocyte differentiation from human pluripotent stem cells and the creation of cardiomyocytes by direct reprogramming strategies, as well as discuss their limitations.

Keywords: Cardiomyocyte, cardiac differentiation, direct reprogramming, pluripotent stem cells, microRNA, forward programming.


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