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CNS & Neurological Disorders - Drug Targets


ISSN (Print): 1871-5273
ISSN (Online): 1996-3181

Sundowning Syndrome: A Possible Marker of Frailty in Alzheimer’s Disease?

Author(s): Davide Ferrazzoli, Francesco Sica and Giuseppe Sancesario

Volume 12 , Issue 4 , 2013

Page: [525 - 528] Pages: 4

DOI: 10.2174/18715273113129990065

Price: $65


The term “sundowning” describes a clinical phenomenon characterized by late afternoon exacerbation of behavioural symptoms in dementia. Beyond this clinical definition, the debate around this concept is not properly solved, because many authors define it in different ways, mentioning various hypothetical etiological explanations. It represents a concrete problem, which is difficult to manage for physicians and caregivers, and is probably linked to various biological, psychological and social aspects. As recently reported, the sundowning phenomenon is a predictor of faster cognitive decline in Alzheimer’s disease, and as such can represent a possible marker of frailty in this illness. This article presents an overview of the biological understanding and possible pharmacological and non-pharmacological treatment of this condition.

Keywords: Alzheimer’s disease, sundowning, frailty, sleep disorder, disrupted circadian rhythm.

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