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Current Pharmaceutical Design

Editor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

From Gastroprotective to Ulcerogenic Effects of Glucocorticoids: Role of Long-Term Glucocorticoid Action

Author(s): Ludmila Filaretova, Tatiana Podvigina, Tatiana Bagaeva and Olga Morozova

Volume 20 , Issue 7 , 2014

Page: [1045 - 1050] Pages: 6

DOI: 10.2174/13816128113199990419

Price: $65

Abstract

Glucocorticoids may have dual action on the gastric mucosa: gastroprotective and ulcerogenic. In this article, we review the data which suggested that an initial action of endogenous glucocorticoids, including stress-produced ones as well as exogenous glucocorticoids is gastroprotective and consider possible mechanisms of the conversion of physiological gastroprotective action of glucocorticoid hormones to their pathological ulcerogenic effect.

Keywords: The hypothalamic-pituitary-adrenocortical axis, glucocorticoids, dexamethasone, gastric mucosa, stress, indomethacin, injury, gastroprotection.


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