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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Hypoxia-inducible Factor-1alpha: Molecular-targeted Therapy for Hepatocellular Carcinoma

Author(s): Z. Z. Dong, M. Yao, L. Wang, W. Wu, X. Gu and D. F. Yao

Volume 13 , Issue 9 , 2013

Page: [1295 - 1304] Pages: 10

DOI: 10.2174/1389557511313090004

Price: $65

Abstract

Hypoxia-inducible factor (HIF)-1α is over-expressed in hepatocellular carcinoma (HCC) and degraded by ubiquitin-proteasome pathways under normoxic conditions. Hepatocyte hypoxia enhances proliferation, angiogenesis, metastasis, chemoresistance, and radioresistance of HCC. The importance role of HIF-1α expression in HCC may improve the prognostic and therapeutic technique. This article reviews the HIF-1α expression and its gene during the rat HCC development, the level of HIF-1α expression in HCC patients, and the effect of silencing HIF-1α gene by miRNA on inhibition of HepG2 cell proliferation.

Keywords: Hepatocellular carcinoma, hypoxia-inducible factor-1alpha, vascular endothelial growth factor, angiopoietin-2, and molecular-targeted therapy.


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