Abstract
The biological roles of mitochondrial-produced reactive oxygen species continue to receive intensive investigation since one of the products (H2O2) has important cellular signaling roles as well as contributing to apoptotic responses. In general, the source of mitochondrial reactive oxygen species is thought to be the superoxide anion produced from Complex I and Complex III components of the electron transport chain. Superoxide anion readily dismutates to H2O2 with subsequent transformation to the hydroxyl radical by Fenton chemistry. An overlooked source of H2O2 in the mitochondrion is its production as a catalytic reaction product from the outer membrane enzymes: monoamine oxidases A and B. The literature is reviewed to document identified degenerative reactions attributed to H2O2 produced by MAO A and by MAO B catalysis. Available information on the topologies of these enzymes in the mitochondrial outer membrane is also discussed with relevance to H2O2 production and involvement in cell signaling functions as well as degenerative effects.
Keywords: Monoamine oxidases A and B, amine oxidation, mitochondrial outer membrane, mitochondrial intermembrane space, membrane topology, reactive oxygen species, hydrogen peroxide, hydroxyl radical.
Current Pharmaceutical Design
Title:Hydrogen Peroxide Produced by Mitochondrial Monoamine Oxidase Catalysis: Biological Implications
Volume: 20 Issue: 2
Author(s): Dale E. Edmondson
Affiliation:
Keywords: Monoamine oxidases A and B, amine oxidation, mitochondrial outer membrane, mitochondrial intermembrane space, membrane topology, reactive oxygen species, hydrogen peroxide, hydroxyl radical.
Abstract: The biological roles of mitochondrial-produced reactive oxygen species continue to receive intensive investigation since one of the products (H2O2) has important cellular signaling roles as well as contributing to apoptotic responses. In general, the source of mitochondrial reactive oxygen species is thought to be the superoxide anion produced from Complex I and Complex III components of the electron transport chain. Superoxide anion readily dismutates to H2O2 with subsequent transformation to the hydroxyl radical by Fenton chemistry. An overlooked source of H2O2 in the mitochondrion is its production as a catalytic reaction product from the outer membrane enzymes: monoamine oxidases A and B. The literature is reviewed to document identified degenerative reactions attributed to H2O2 produced by MAO A and by MAO B catalysis. Available information on the topologies of these enzymes in the mitochondrial outer membrane is also discussed with relevance to H2O2 production and involvement in cell signaling functions as well as degenerative effects.
Export Options
About this article
Cite this article as:
Edmondson E. Dale, Hydrogen Peroxide Produced by Mitochondrial Monoamine Oxidase Catalysis: Biological Implications, Current Pharmaceutical Design 2014; 20 (2) . https://dx.doi.org/10.2174/13816128113190990406
DOI https://dx.doi.org/10.2174/13816128113190990406 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
Call for Papers in Thematic Issues
"Tuberculosis Prevention, Diagnosis and Drug Discovery"
The Nobel Prize-winning discoveries of Mycobacterium tuberculosis and streptomycin have enabled an appropriate diagnosis and an effective treatment of tuberculosis (TB). Since then, many newer diagnosis methods and drugs have been saving millions of lives. Despite advances in the past, TB is still a leading cause of infectious disease mortality ...read more
Current Pharmaceutical challenges in the treatment and diagnosis of neurological dysfunctions
Neurological dysfunctions (MND, ALS, MS, PD, AD, HD, ALS, Autism, OCD etc..) present significant challenges in both diagnosis and treatment, often necessitating innovative approaches and therapeutic interventions. This thematic issue aims to explore the current pharmaceutical landscape surrounding neurological disorders, shedding light on the challenges faced by researchers, clinicians, and ...read more
Emerging and re-emerging diseases
Faced with a possible endemic situation of COVID-19, the world has experienced two important phenomena, the emergence of new infectious diseases and/or the resurgence of previously eradicated infectious diseases. Furthermore, the geographic distribution of such diseases has also undergone changes. This context, in turn, may have a strong relationship with ...read more
Melanoma and Non-Melanoma Skin Cancer Treatment: Standard of Care and Recent Advances
In this thematic issue, we aim to provide a standard of care of the diagnosis and treatment of melanoma and non-melanoma skin cancer. The editor will invite authors from different countries who will write review articles of melanoma and non-melanoma skin cancers. The Diagnosis, Staging, Surgical Treatment, Non-Surgical Treatment all ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Editorial: Modifying Cardiovascular Risk Factors: Acquired Topics and Emerging Concepts
Current Pharmaceutical Design Can Wogonin be Used in Controlling Diabetic Cardiomyopathy?
Current Pharmaceutical Design Normal Ventricular Functional Reference Parameters on Magnetic Resonance Imaging in Healthy Children
Current Medical Imaging Role of Nitric Oxide and Mitochondrial Nitric Oxide Synthase in Energy Adaptive Responses
Current Cardiology Reviews Stem Cells Therapies in Basic Science and Translational Medicine: Current Status and Treatment Monitoring Strategies
Current Pharmaceutical Biotechnology Cardio-Vascular Risks Associated with Clozapine Treatment
Current Psychiatry Reviews Atrial Tachycardias Arising from the Atrial Appendages and Aortic Sinus of Valsalva
Current Cardiology Reviews Are the Antioxidant Properties of Carvedilol Important for the Protection of Cardiac Mitochondria?
Current Vascular Pharmacology Gene Replacement Therapies for Duchenne Muscular Dystrophy Using Adeno-Associated Viral Vectors
Current Gene Therapy Induction and Escalation Therapies in Multiple Sclerosis
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Editorial (Thematic Issue: Cardiac Imaging in the Diagnosis of Coronary Artery Disease: A Comprehensive Overview of Various Imaging Modalities)
Current Medical Imaging Gender Differences in Response to Therapy for Cardiovascular Diseases
Current Pharmacogenomics and Personalized Medicine Prevalence of Dilated Cardiomyopathy in HIV-Infected African Patients Not Receiving HAART: A Multicenter, Observational, Prospective, Cohort Study in Rwanda
Current HIV Research Current Nervous System Related Drug Targets for the Treatment of Amyotrophic Lateral Sclerosis
Current Pharmaceutical Design Promises of Lipid-based Drug Delivery Systems in the Management of Breast Cancer
Current Pharmaceutical Design COVID-19 Invades Several Important Organs other than the Lungs: Organs Crosstalk
Coronaviruses Fabry Disease Cardiomyopathy: from Genes to Clinical Manifestations
Current Pharmaceutical Biotechnology Ryanodine Receptor as Insecticide Target
Current Pharmaceutical Design Dietary Carbohydrates that Modulate the Immune System
Clinical Immunology, Endocrine & Metabolic Drugs (Discontinued) Editorial (Thematic Issue: Managing Strategies for Diverse Diseases: Challenges from Bench to Bedside Translation in Successful Drug Discovery and Development (Part B))
Current Pharmaceutical Design