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Combinatorial Chemistry & High Throughput Screening


ISSN (Print): 1386-2073
ISSN (Online): 1875-5402

Solvent-Free Synthesis of Functionalized Thiazoles Using Multicomponent Reaction of Isothiocyanates

Author(s): Seyyedeh Zahra Sayyed-Alangi, Zinatossadat Hossaini, Faramarz Rostami-Charati and Hadi Sajjadi-Ghotabadi

Volume 16 , Issue 9 , 2013

Page: [758 - 761] Pages: 4

DOI: 10.2174/13862073113169990036

Price: $65


An efficient synthesis of thiazoles is described via an one-pot reaction between acid chlorides, ammonium thiocyanate tetramethylguanidine and α-bromocarbonyl compounds under solvent-free conditions without using any catalyst. The method offers several advantages including high yields of products and an easy work-up procedure at room temperature in excellent yield.

Keywords: Arylisothiocyanates, one-pot reactions, tetramethylguanidine, thiazoles.

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