Abstract
The formation of collateral vessels (arteriogenesis) to sustain perfusion in ischemic tissue is native to the body and can compensate for coronary stenosis. However, arteriogenesis is a complex process and is dependent on many different factors. Although animal studies on collateral formation and stimulation show promising data, clinical trials have failed to replicate these results. Further research to the exact mechanisms is needed in order to develop a pharmalogical stimulant. This review gives an overview of recent data in the field of arteriogenesis.
Keywords: Arteriogenesis, CAD, collateral, endothelium, growth factors, proliferation, SMC.
Current Cardiology Reviews
Title:Cellular and Pharmacological Targets to Induce Coronary Arteriogenesis
Volume: 10 Issue: 1
Author(s): Maurits R. Hollander, Anton J.G. Horrevoets and Niels van Royen
Affiliation:
Keywords: Arteriogenesis, CAD, collateral, endothelium, growth factors, proliferation, SMC.
Abstract: The formation of collateral vessels (arteriogenesis) to sustain perfusion in ischemic tissue is native to the body and can compensate for coronary stenosis. However, arteriogenesis is a complex process and is dependent on many different factors. Although animal studies on collateral formation and stimulation show promising data, clinical trials have failed to replicate these results. Further research to the exact mechanisms is needed in order to develop a pharmalogical stimulant. This review gives an overview of recent data in the field of arteriogenesis.
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Cite this article as:
Hollander R. Maurits, Horrevoets J.G. Anton and Royen van Niels, Cellular and Pharmacological Targets to Induce Coronary Arteriogenesis, Current Cardiology Reviews 2014; 10 (1) . https://dx.doi.org/10.2174/1573403X113099990003
DOI https://dx.doi.org/10.2174/1573403X113099990003 |
Print ISSN 1573-403X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6557 |
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