Abstract
The present review deals with the C-prenylation of phenolic compounds, the topic has even gained a considerable scientific attention but still poorly described in the literature. A brief introduction on natural sources of C-prenylated phenolics is highlighted in the first lines, underlining also few of the recent studies on identification, biological applications and biosynthesis of mainly C-prenylflavonoids and -xanthones along with other small C-prenylated phenolic molecules. The paper is majorly focusing on the organic synthetic aspects, throughout, a hundred of papers are reviewed since 1970; most of them have been published during the last decade. A chronological dialogue is presented in order to find out the research progress on the synthesis of this important class of natural compounds; a quite number of synthetic products show higher biological impact than the natural models.
Keywords: C-prenylation, Prenyl, Isoprenyl, Geranyl, Farnesyl, 3-methylbut-2-en-1-yl, Prenyl bromide, 2-hydroxy-2-methylbut-3-ene, Flavonoids, Xanthones, Organic synthesis, Natural occurrence, Biological activity, Biosynthesis.
Current Organic Chemistry
Title:Organic Synthesis of C-Prenylated Phenolic Compounds
Volume: 17 Issue: 10
Author(s): Oualid Talhi and Artur M. S. Silva
Affiliation:
Keywords: C-prenylation, Prenyl, Isoprenyl, Geranyl, Farnesyl, 3-methylbut-2-en-1-yl, Prenyl bromide, 2-hydroxy-2-methylbut-3-ene, Flavonoids, Xanthones, Organic synthesis, Natural occurrence, Biological activity, Biosynthesis.
Abstract: The present review deals with the C-prenylation of phenolic compounds, the topic has even gained a considerable scientific attention but still poorly described in the literature. A brief introduction on natural sources of C-prenylated phenolics is highlighted in the first lines, underlining also few of the recent studies on identification, biological applications and biosynthesis of mainly C-prenylflavonoids and -xanthones along with other small C-prenylated phenolic molecules. The paper is majorly focusing on the organic synthetic aspects, throughout, a hundred of papers are reviewed since 1970; most of them have been published during the last decade. A chronological dialogue is presented in order to find out the research progress on the synthesis of this important class of natural compounds; a quite number of synthetic products show higher biological impact than the natural models.
Export Options
About this article
Cite this article as:
Talhi Oualid and Silva Artur M. S., Organic Synthesis of C-Prenylated Phenolic Compounds, Current Organic Chemistry 2013; 17 (10) . https://dx.doi.org/10.2174/1385272811317100009
DOI https://dx.doi.org/10.2174/1385272811317100009 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
Call for Papers in Thematic Issues
Advances of Heterocyclic Chemistry with Pesticide Activity
Global food safety and security will continue to be a global concern for the next 50 years and beyond. Plant diseases have had a significant impact on food safety and security throughout the entire food chain, from primary production to consumption. While conventional chemical pesticides have been traditionally used for ...read more
Calculation design of covalent/metal organic framework based catalysts
This research area combines theoretical computation and screening with machine learning for the design of covalent/metal organic framework-based catalysts, bridging the disciplines of organic chemistry, physical chemistry, computational chemistry, materials science, and machine learning. It covers several critical aspects: designing and synthesizing organic catalysts for improved performance, applying computational methods ...read more
Carbohydrates conversion in biofuels and bioproducts
Biomass pretreatment, hydrolysis, and saccharification of carbohydrates, and sugars bioconversion in biofuels and bioproducts within a biorefinery framework. Carbohydrates derived from woody biomass, agricultural wastes, algae, sewage sludge, or any other lignocellulosic feedstock are included in this issue. Simulation, techno-economic analysis, and life cycle analysis of a biorefinery process are ...read more
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Novel Antiinflammatory and Antiinfective Agents
Anti-Infective Agents in Medicinal Chemistry Evaluation of In Vivo Efficacy of Aqueous Extract of Aerial Parts of Cynodon dactylon in Rats with Simultaneous Type 2 Diabetes and Hypertension
Current Bioactive Compounds Study of Convolvulus pluricaulis for Antioxidant and Anticonvulsant Activity
Central Nervous System Agents in Medicinal Chemistry The Effect of Antihypertensive Drugs on Central Blood Pressure Beyond Peripheral Blood Pressure. Part II: Evidence for Specific Class-Effects of Antihypertensive Drugs on Pressure Amplification
Current Pharmaceutical Design Medicinal Plants and Bioactive Compounds for Diabetes Management: Important Advances in Drug Discovery
Current Pharmaceutical Design Monoamine Oxidase-B (MAO-B) Inhibitors in the Treatment of Alzheimer’s and Parkinson’s Disease
Current Medicinal Chemistry Diquaternized Curarelike Myorelaxants: Structure and Biological Activity
Mini-Reviews in Medicinal Chemistry Secondary Hypertension: The Ways of Management
Current Vascular Pharmacology Adverse HBOC-Endothelial Dysfunction Synergism: A Possible Contributor to Adverse Clinical Outcomes?
Current Drug Discovery Technologies Biochemical Markers for Brain Injury Monitoring in Children with or without Congenital Heart Diseases
CNS & Neurological Disorders - Drug Targets Pathogenesis of Diabetic Retinopathy and Diabetic Macular Edema and Enzyme Inhibition
Current Enzyme Inhibition Current Pharmacologic Management of Pediatric Heart Failure in Congenital Heart Disease
Current Vascular Pharmacology Mas Receptor Agonists as Novel Antihypertensive Agents
Current Hypertension Reviews Functional Roles of Benzothiazole Motif in Antiepileptic Drug Research
Mini-Reviews in Medicinal Chemistry Anti-Vascular Endothelial Growth Factor (VEGF) Therapy: A New Cause of Hypertension
Current Hypertension Reviews The Immunological Side-Effects of Sedative Agents in the Intensive Care Unit
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Current Status and Future of Antifungal Therapy for Systemic Mycoses
Recent Patents on Anti-Infective Drug Discovery Vaccine Development for Group A Streptococcus Infections and Associated Diseases
Current Drug Targets Polyglandular Autoimmune Syndromes
Current Immunology Reviews (Discontinued) Safety and Efficacy of Melatonin in Pediatric Migraine Prophylaxis
Current Drug Safety