Abstract
There is a profound need for orthopaedic grafting strategies due to various trauma and musculoskeletal diseases. Tissue engineering offers a promising avenue to develop viable grafts for bone repair. The transfer of bone tissue engineering strategies to clinical applications is limited by the failure to adequately vascularize scaffolds after implantation. This review focuses on the natural processes for bone and vessel formation as well as the microenvironmental cues and microscale fabrication techniques to properly coordinate these events towards successful vascularization of tissue engineered scaffolds.
Keywords: Angiogenesis, tissue engineering, bone, scaffold, microscale patterning, growth factor delivery, cell transplantation.
Current Pharmaceutical Design
Title:Strategies to Direct Angiogenesis within Scaffolds for Bone Tissue Engineering
Volume: 19 Issue: 19
Author(s): Greg M. Harris, Katy Rutledge, Qingsu Cheng, James Blanchette and Ehsan Jabbarzadeh
Affiliation:
Keywords: Angiogenesis, tissue engineering, bone, scaffold, microscale patterning, growth factor delivery, cell transplantation.
Abstract: There is a profound need for orthopaedic grafting strategies due to various trauma and musculoskeletal diseases. Tissue engineering offers a promising avenue to develop viable grafts for bone repair. The transfer of bone tissue engineering strategies to clinical applications is limited by the failure to adequately vascularize scaffolds after implantation. This review focuses on the natural processes for bone and vessel formation as well as the microenvironmental cues and microscale fabrication techniques to properly coordinate these events towards successful vascularization of tissue engineered scaffolds.
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Cite this article as:
Harris Greg M., Rutledge Katy, Cheng Qingsu, Blanchette James and Jabbarzadeh Ehsan, Strategies to Direct Angiogenesis within Scaffolds for Bone Tissue Engineering, Current Pharmaceutical Design 2013; 19 (19) . https://dx.doi.org/10.2174/1381612811319190011
DOI https://dx.doi.org/10.2174/1381612811319190011 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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