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Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Pharmacogenomic Approaches for Tailored Anti-Leukemic Therapy in Children

Author(s): G. Stocco, R. Franca, F. Verzegnassi, M. Londero, M. Rabusin and G. Decorti

Volume 20 , Issue 17 , 2013

Page: [2237 - 2253] Pages: 17

DOI: 10.2174/0929867311320170008

Price: $65

Abstract

Several lympholytic and cytotoxic agents are used in acute lymphoblastic leukemia (ALL) polychemotherapy. Genetic variants for cellular components involved in the pharmacokinetics and pharmacodynamics of these drugs can influence the pharmacological response, and molecular characterization of these genetic variants could be helpful for the comprehension of the mechanisms of resistance or increased sensitivity. The purpose of this review is to carry out an update of recent publications on genes that might influence ALL treatment in terms of outcome and/or toxicity and to underlie the role of genetic variants, particularly single nucleotide polymorphisms (SNP), in predicting clinical response, with particular reference to the current protocol for ALL therapy used in Italy, AIEOP-BFM ALL 2009.

Keywords: Acute lymphoblastic leukemia, chemotherapy, pharmacogenetics.


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