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Current Organic Chemistry


ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

Recent Advances in Fluorescent Probes for the Detection of Hydrogen Sulfide

Author(s): Hanjing Peng, Weixuan Chen, Sarah Burroughs and Binghe Wang

Volume 17 , Issue 6 , 2013

Page: [641 - 653] Pages: 13

DOI: 10.2174/1385272811317060007


Hydrogen sulfide (H2S) has been recognized as one of the three important gasotransmitters along with nitric oxide (NO) and carbon monoxide (CO). H2S plays regulatory roles in the cardiovascular system (CV), central nervous system (CNS), respiratory system, gastrointestinal system, and endocrine system. The study to understand its molecular mechanism is still ongoing. Current methods for the detection of H2S include chromatographic methods, electrochemical methods, and colorimetric/fluorometric methods. Fluorescent sensors and probes are especially important in modern analysis due to their high sensitivity, which can provide nanomolar detection; their compatibility with high-throughput screening (HTS), which allows for rapid assessment; and their applicability in live cell bioimaging, which allows real-time detection/observation. This review focuses on strategies used in designing fluorescent sensors and probes for H2S and their applications.

Keywords: Cell imaging, Detection methods, Fluorescent probes, Fluorescent sensors, Gasotransmitters, Hydrogen sulfide

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