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Inflammation & Allergy - Drug Targets (Discontinued)

Editor-in-Chief

ISSN (Print): 1871-5281
ISSN (Online): 2212-4055

Inhalation Delivery of Protein Therapeutics

Author(s): Colleen Kane, Karyn O’Neil, Michelle Conk and Kristen Picha

Volume 12 , Issue 2 , 2013

Page: [81 - 87] Pages: 7

DOI: 10.2174/1871528111312020002

Price: $65

Abstract

Inhaled therapeutics are used routinely to treat a variety of pulmonary diseases including asthma, COPD and cystic fibrosis. In addition, biological therapies represent the fastest growing segment of approved pharmaceuticals. However, despite the increased availability of biological therapies, nearly all inhaled therapeutics are small molecule drugs with only a single inhaled protein therapeutic approved. There remains a significant unmet need for therapeutics in pulmonary diseases, and biological therapies with potential to alter disease progression represent a significant opportunity to treat these challenging diseases. This review provides a background into efforts to develop inhaled biological therapies and highlights some of the associated challenges. In addition, we speculate on the ideal properties of a biologic therapy for inhaled delivery.

Keywords: Alternative scaffolds, inhalation, protein therapeutics, pulmonary delivery.


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