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Combinatorial Chemistry & High Throughput Screening


ISSN (Print): 1386-2073
ISSN (Online): 1875-5402

Nitrogen Containing Privileged Structures and their Solid Phase Combinatorial Synthesis

Author(s): Amit Verma, Mange Ram Yadav, Rajani Giridhar, Navnit Prajapati, Avinash C. Tripathi and Shailendra K. Saraf

Volume 16 , Issue 5 , 2013

Page: [345 - 393] Pages: 49

DOI: 10.2174/1386207311316050003

Price: $65


The existence of preferred molecular scaffolds that possess inherent biological activity, called privileged structures, is now well recognized. Such privileged structures not only provide enhanced drug-like properties but also give new hits for developing leads. The synthesis of combinatorial libraries, especially with the insertion of privileged substructures into heterocyclic moieties containing nitrogen, provides for a greater probability of the discovery of novel lead compounds using chemical transformation. The review focuses on the progress in the solid-phase synthetic strategies of nitrogen containing privileged structures over the years.

Keywords: Benzodiazepine, combinatorial synthesis, cyclic peptides, nitrogen heterocyclics, privileged structures, purines and pyrimidines, solid-phase synthesis.

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