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Current Drug Targets


ISSN (Print): 1389-4501
ISSN (Online): 1873-5592

Evolving Therapeutic Targets in Ischemic Stroke: A Concise Review

Author(s): Sinoy Sugunan, Diya Binoy Joseph and G. K. Rajanikant

Volume 14 , Issue 4 , 2013

Page: [497 - 506] Pages: 10

DOI: 10.2174/1389450111314040011

Price: $65


Ischemic stroke is the leading cause of mortality and morbidity worldwide for which the assemblage of therapeutic interventions has remained outstandingly limited. Several new insights into the causes of neuronal death during ischemic event have led to the identification of some important novel targets for intervention. This article highlights some of the promising protein targets, which are in the validation process and have the potential to get translated into viable neurotherapeutics against ischemic stroke.

Keywords: Ischemic stroke, therapeutic targets, excitotoxicity, NADPH oxidase, inflammation, MHC-I, neuroplasticity

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