Generic placeholder image

Reviews on Recent Clinical Trials

Editor-in-Chief

ISSN (Print): 1574-8871
ISSN (Online): 1876-1038

Effect of Non-Steroidal Anti-Inflammatory Drugs on Bone Turnover: An Evidence-Based Review

Author(s): Ioannis Konstantinidis, Spyridon N. Papageorgiou, Athanassios Kyrgidis, Thrasivoulos- George Tzellos and Dimitrios Kouvelas

Volume 8 , Issue 1 , 2013

Page: [48 - 60] Pages: 13

DOI: 10.2174/1574887111308010008

Price: $65

Abstract

Nonsteroidal anti-inflammatory drugs (NSAIDs) are frequently used for acute and chronic pain control and treatment of inflammation, osteoarthritis and rheumatoid arthritis. NSAIDs have been shown to inhibit bone healing in animal studies due to the inhibition of prostaglandin synthesis. However, little evidence exists regarding the effect of NSAID exposure on human bone metabolism. This systematic review summarizes the current literature of randomized controlled trials (RCTs) investigating NSAIDs with bone remodeling-related outcomes in humans. After performing computerized searches in the most widely indexed databases, study selection, data abstraction and risk of bias assessment were conducted in duplicate. The results were controversial regarding the association of NSAID with bone formation or resorption. Increased bone mineral density following NSAID exposure was reported by some studies. Based on the levels of biochemical markers, no effect was seen on bone formation, while some evidence was found for a decreased rate of bone resorption in NSAID patients. Trials investigating the effects of NSAID treatment on bone metabolism outcomes of human patients are limited. Further research is required to confirm or refute the findings of this systematic review.

Keywords: Bone metabolism, bone remodeling, non-steroidal anti-inflammatory drug, randomized controlled trial, chronic, osteoarthritis, rheumatoid arthritis, prostaglandin synthesis, biochemical, Bone homeostasis


Rights & Permissions Print Export Cite as
© 2022 Bentham Science Publishers | Privacy Policy