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Cardiovascular & Hematological Agents in Medicinal Chemistry


ISSN (Print): 1871-5257
ISSN (Online): 1875-6182

Diabetic CVD – Focus on Vitamin D

Author(s): Shokoufeh Bonakdaran and Haleh Rokni

Volume 10 , Issue 3 , 2012

Page: [241 - 250] Pages: 10

DOI: 10.2174/187152512802651088

Price: $65


Cardiovascular disease (CVD) is the leading cause of mortality and morbidity among diabetics. Vitamin D deficiency is very common all over the world. Over last few years, vitamin D has been considered as an important regulating factor for cardiovascular health. Metabolic syndrome and obesity are highly prevalent in vitamin D deficient people. In fact all components of metabolic syndrome are affected by vitamin D. Vitamin D regulates insulin secretion and its action. It has also some controlling effect on Renin-Angiotensin system, which influences cardiomyocytes positively. Vitamin D plays a role in vascular system too. This vitamin reduces vascular calcification and inflammatory processes. Given the important role of Vitamin D in cardiovascular health, this review focuses on the impacts of vitamin D on the various CVD risk factors.

Keywords: Albuminuria, Cardiovascular Disease, congestive heart failure, Diabetes, hypertension, inflammation, insulin resistance, Metabolic Syndrome, obesity, Vitamin D

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