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Recent Patents on DNA & Gene Sequences

Editor-in-Chief

ISSN (Print): 1872-2156
ISSN (Online): 2212-3431

Advances in Lentiviral Vectors: A Patent Review

Author(s): Virginia Picanco-Castro, Elisa Maria de Sousa Russo-Carbolante and Dimas Tadeu Covas

Volume 6 , Issue 2 , 2012

Page: [82 - 90] Pages: 9

DOI: 10.2174/187221512801327433

Price: $65

Abstract

Lentiviral vectors are at the forefront of gene delivery systems for research and clinical applications. These vectors have the ability to efficiently transduce nondividing and dividing cells, to insert large genetic segment in the host chromatin, and to sustain stable long-term transgene expression. Most of lentiviral vectors systems in use are derived from HIV-1. Numerous modifications in the basic HIV structure have been made to ensure safety and to promote efficiency to vectors. Lentiviral vectors can be pseudotyped with distinct viral envelopes that influence vector tropism and transduction efficiency. Moreover, these vectors can be used to reprogram cells and generate induced pluripotent stem cells. This review aims to show the patents that resulted in improved safety and efficacy of lentiviral vector with important implications for clinical trials.

Keywords: Lentiviral vectors, vector design, applications, vector tropism, pluripotent stem cells, Retroviridae, Simian immunodeficiency virus, Feline immunodeficiency virus


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