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Current Pharmaceutical Design

Editor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

The Dialogue Between Endothelial Cells and Monocytes/Macrophages in Vascular Syndromes

Author(s): J. Martin, S. Collot-Teixeira, L. McGregor and J. L. McGregor

Volume 13 , Issue 17 , 2007

Page: [1751 - 1759] Pages: 9

DOI: 10.2174/138161207780831248

Price: $65

Abstract

The aim of this chapter is to present and identify potential pharmacological targets in endothelial cell-monocyte interactions leading to vascular syndrome and involving inflammation, coagulation, vascular remodelling and thrombosis. Increasing evidence is indicating that endothelial cells play a key role in atherothombosis by their capacity to attract, bind and allow the extravasation of monocytes to sites of inflammation. Surface expression and/or activation of constituent cell adhesion molecules (for e.g. P-selectin, E-selectin, ICAM-1, and VCAM-1) on endothelial cells together with chemokines such as CXCL8 (IL-8), Platelet-activating factor (PAF), CCL2 and CCL5 (Table 1) allow the rolling, adhesion and extravasation of monocytes. This review focuses on pharmacological targets implicated in endothelial cells interactions with monocytes/macrophages in vascular disease states and on cutting edge genomic tools for the identification and characterization of such targets.

Keywords: Inflammation, endothelial cells, monocytes/macrophages, cell adhesion molecules, chemokines, polymorphisms, genomic tools


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