Abstract
Pharmacogenomics, applied as an aspect of molecular autopsy, might become an integral part of forensic medicine in the near future. Pharmacogenomics is the study of the relationship between an individuals genetic/genomic information and the disposition/response to medications. As a result, pharmacogenomics may provide a deeper mechanistic insight necessary for forensic pathologists to fully understand/interpret postmortem toxicology results and correctly determine the cause and manner of death. In this paper, the use of pharmacogenomics as a molecular autopsy tool to raise the standards in forensic medicine is discussed, and illustrated with selected cases. In addition, the current limitations and hurdles for using pharmacogenomics in the postmortem forensic setting are also reviewed.
Keywords: Forensic medicine, forensic pathology, forensic toxicology, pharmacogenomics, postmortem toxicology, standards
Current Pharmacogenomics and Personalized Medicine
Title: Forensic Toxicology and Pharmacogenomics: Hype or Hope For Higher Standards in Forensic Medicine?
Volume: 8 Issue: 2
Author(s): Paul J. Jannetto, Nancy C. Bratanow and Agnieszka Rogalska
Affiliation:
Keywords: Forensic medicine, forensic pathology, forensic toxicology, pharmacogenomics, postmortem toxicology, standards
Abstract: Pharmacogenomics, applied as an aspect of molecular autopsy, might become an integral part of forensic medicine in the near future. Pharmacogenomics is the study of the relationship between an individuals genetic/genomic information and the disposition/response to medications. As a result, pharmacogenomics may provide a deeper mechanistic insight necessary for forensic pathologists to fully understand/interpret postmortem toxicology results and correctly determine the cause and manner of death. In this paper, the use of pharmacogenomics as a molecular autopsy tool to raise the standards in forensic medicine is discussed, and illustrated with selected cases. In addition, the current limitations and hurdles for using pharmacogenomics in the postmortem forensic setting are also reviewed.
Export Options
About this article
Cite this article as:
J. Jannetto Paul, C. Bratanow Nancy and Rogalska Agnieszka, Forensic Toxicology and Pharmacogenomics: Hype or Hope For Higher Standards in Forensic Medicine?, Current Pharmacogenomics and Personalized Medicine 2010; 8 (2) . https://dx.doi.org/10.2174/187569210791383947
DOI https://dx.doi.org/10.2174/187569210791383947 |
Print ISSN 1875-6921 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6913 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
GLP - 1 Analogs: Newer Molecules, Newer Uses
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery Nimodipine Reappraised: An Old Drug With a Future
Current Neuropharmacology Review of Recent Clinical Developments and Patents for the Treatment of Autoimmune and Inflammatory Diseases by Mesenchymal Stromal Cells
Recent Patents on Regenerative Medicine Peripheral Blood Derived Cell Trafficking for Cardiac Regeneration
Current Stem Cell Research & Therapy EDITORIAL [Hot Topic: Diabetes Cardiovascular Complications (Guest Editor: Costanza Emanueli)]
Endocrine, Metabolic & Immune Disorders - Drug Targets A Mitochondrial Approach to Cardiovascular Risk and Disease
Current Pharmaceutical Design Aetiology, Diagnosis and Treatment of Hydrops Foetalis
Current Pediatric Reviews Nanotechnological Strategies for the Treatment of Neglected Diseases
Current Pharmaceutical Design Link between Metabolic Syndrome and Insulin Resistance
Current Vascular Pharmacology Editorial (Thematic Issue: The Long Way to a Successful Medical Therapy of Heart Failure with Beta-blockers in Children with Heart Disease)
Reviews on Recent Clinical Trials The Mechanism of Carvedilol in Experimental Viral Myocarditis
Current Pharmaceutical Design Ectodomain Shedding of ACE and ACE2 as Regulators of Their Protein Functions
Current Enzyme Inhibition Cardiac Calmodulin Kinase: A Potential Target for Drug Design
Current Medicinal Chemistry Redox Processes in Neurodegenerative Disease Involving Reactive Oxygen Species
Current Neuropharmacology Transient Receptor Potential Channels - Emerging Novel Drug Targets for the Treatment of Pain
Current Medicinal Chemistry Clinical Vignettes: Integrated Care of Cancer Patients by Oncologists and Cardiologists
Current Cardiology Reviews Actionable Nutrigenetics for Genetically Based Diseases? A New Critical Path to P4 Medicine
Current Pharmacogenomics and Personalized Medicine Effects of Mesenchymal Stromal Cells on Diabetic Cardiomyopathy
Current Pharmaceutical Design Cardiovascular Side Effects of New Antidepressants and Antipsychotics: New Drugs, old Concerns?
Current Pharmaceutical Design Susceptibility Risk Alleles of -238G/A, -308G/A and -1031T/C Promoter Polymorphisms of TNF-α Gene to Uterine Leiomyomas
Recent Advances in DNA & Gene Sequences (Discontinued)