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Current Pharmacogenomics and Personalized Medicine

Editor-in-Chief

ISSN (Print): 1875-6921
ISSN (Online): 1875-6913

Computational Simulations of the Immune System for Personalized Medicine: State of the Art and Challenges

Author(s): Francesco Pappalardo, Ping Zhang, Mark Halling-Brown, Kaye Basford, Antonio Scalia, Adrian Shepherd, David Moss, Santo Motta and Vladimir Brusic

Volume 6 , Issue 4 , 2008

Page: [260 - 271] Pages: 12

DOI: 10.2174/187569208786733839

Price: $65

Abstract

The main goal of pharmacogenomics is to study the effects of genetic variation on patient responses to therapies. Its applications range from the evaluation of safety and efficacy of treatment to the optimization of therapies and therapeutic regimens. Pharmacogenomics is becoming increasingly important in immunology, for the development of new generation vaccines, immunotherapies and transplantation. The human immune system is a complex and adaptive learning system which operates at multiple levels: molecules, cells, organs, organisms, and groups of organisms. Immunologic research, both basic and applied, needs to deal with this complexity. We increasingly use mathematical modeling and computational simulation in the study of the immune system and immune responses. Thus, quantitative models that appropriately capture the complexity in architecture and function of the immune system are an integral component of the personalized medicine efforts. In silico models of the immune system can provide answers to a variety of questions, including understanding the general behavior of the immune system, the course of disease, effects of treatment, analysis of cellular and molecular interactions, and simulation of laboratory experiments. We herein present the ImmunoGrid project that integrates molecular and system level models of the immune system and processes for in silico studies of the immune function. The ImmunoGrid simulator uses Grid technologies, enabling computational simulation of the immune system at the natural scale, perform a large number of simulated experiments, capture the diversity of the immune system between individuals, and provide a basis for therapeutic approaches tailored to the individual genetic make-up.

Keywords: Pharmacogenomics applications, pharmacogenomics in personalized medicine, computational modeling, immune system simulation, ImmunoGrid


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